The Egg Retrieval Day ... I woke up excited and hopeful about my future family. Granted there are no guarantees, but I was predicting about 11-13 mature eggs and I had it ingrained in my mind that I only needed approximately 10 of those to make a baby. Therefore, I felt the odds were in my favor.
I got to the office waiting room on time only to wait an additional 45 minutes to be taken back to get prepped for surgery. I was getting nervous, because from the trigger shot of HCG to the release of the eggs is 36 hours and we did not have a lot of wiggle room. The eggs won't wait on traffic. They release on their own time frame. I remember briefly talking to the anesthesiologist about when I could get alcohol in my system again. No, I am not an alcoholic, nor do I drink everyday. However, these past two plus weeks have been the longest time I have abstained from alcohol since before college. It was a master cleanse of some kind for me. No alcohol, caffeine, sexual activity, or rigorous exercise for 16 days. If I could pinpoint what was the most difficult for me to give up, I would have to say the intense working out. I love to eat and the way I keep my somewhat girlish figure is by burning calories from running, cross fit, and biking. It was a bit of a letdown that I found out that I would need to wait an additional 10 days post surgery before I could start running again. If you work out too early, you run the risk of ovarian torsion, and could have to amputate your ovary if it gets severely damaged. Surgery can repair the damage though for most people. The reasoning is that your ovaries are majorly enlarged after the stimulation drugs and once the eggs are removed, the ovaries are a little slower to respond*. Patients with ovarian torsion often present with sudden onset of sharp and usually unilateral lower abdominal pain, in 70% of cases accompanied by nausea and vomiting.
It should actually be given in your
stomach area or upper thigh!
My RE doctor decided to stimulate me for one more day and had me trigger on day 14. My estrogen must have been at least 4500 by the trigger shot time. I was prescribed one pre-filled dosage of Ovidrel to take at exactly 35 hours and 30 minutes before my egg retrieval time. On day 13 of stimulations, the bloodwork showed my estrogen was 3955. I had to trust my doctors that they knew what was best for me and one more day of injections would not make too many of my eggs over mature My goal was to get enough good quality eggs in the bank for a future baby down the line, not to implant an embryo a few days after the egg retrieval. Therefore, I was predicted to not be at major risk of major OHSS (Ovarian Hyperstimulation Syndrome).
An aside on weight gain during the egg freezing process ... everyone responds differently. However, there is a general consensus that you will temporarily gain about 5 pounds throughout the two plus weeks of shots and egg retrieval time. I gained only two pounds on the scale during the injections. I will update on the entire weight gain later.
I planned my Sunday evening around the shot. I went to a documentary movie that got out at exactly 9:30. I wanted to be home in time for my prep work for the shot and for any unexpected surprises. I kept the Ovidrel in the refrigerator the entire two weeks. I took it out 15 minutes prior to the shot. No mixing anymore. Yeah! The HCG injection was easy. The aftermath was not. About an hour and a 1/2 later, my stomach started feeling queasy and I had to run to the bathroom. Initially I thought it would go away. No, I spent 1/2 the night up with diarrhea and abdominal cramps. I hate to be so graphic, but I promised full disclosure of my experience and I am not leaving anything out. I finally took Immodium and within 20 minutes, the symptoms subsided and I felt better. I woke up feeling sluggish and a little forgetful. My doctor assured me that everything was normal and the back end release was one on the side effects. I could not have been more excited / nervous for egg retrieval day.
I slept really well the night before. Finally, egg retrieval scheduled at 10:15 AM for the next morning. I am ready. My lower area did feel heavy, but I did not feel incredibly bloated yet.
Here is a video on how to inject the Ovidrel shot for Newbies. Good luck!
Well, I promised full disclosure of my egg freezing cycle and I am keeping my word. I am slightly bloated and craving a work out, but overall I am really functioning at a high level right now.
Here is a chart of my progress throughout my egg freezing cycle. Througout the process, I had my doubts that my little follicles would mature fast enough. Some of it is just anxiety and some of it is real fear based on what I have heard and read about other people's IVF cycles. When estrogen reaches above 4000, the doctors want to trigger ovulation for fear of ovarian hyperstimulation and loss of egg quality. Right now I am on Day 13 waiting for the Go sign to trigger or take one more day of meds. I actually needed to order an extra day of medications just in case I need to stimulate for Day 13. My medications have cost $4800.00 in total for the 13 days. This is with the Heart discount for Menopur and the Go Savings for the Cetrotide and Gonal F. I ordered from Freedom Fertility Pharmacy and I would highly endorse ordering from them. They check the prescriptions, give you free syringes and needles, and deliver exactly when they say they will. Continue on by clicking read more.
Written by: Sam K.For questions or comments, pleasecontact me. Statistics:Age- Turning 37Baseline Stats: AMH-Between .7 - .9FSH6.7LH3.4E215.4 NoDHtospeakofyet. DH in the fertility world stands for Dear Husband. Not giving up hope yet.
Before I took the plunge to sign on the dotted line for the egg freezing process, I did some research on the internet on the success of embryo freezing vs. egg freezing. It gave me conflicting answers. Some sites said that egg freezing was nearly as effective in producing a baby than embryo freezing, while others said entirely the opposite. What I gathered over my three months of research is that embryos are hardier than eggs and that there is a risk on losing more eggs than embryos from dethawing. However, as technology is improving so is our ability to freeze and unfreeze both without fear of killing the cells. I honestly was not ready to give up on my dream to have the father of my unborn, not yet created baby, be a known entity to my child. I still wanted it all. I checked YES to start the process and bought the $4500.00 of drugs I was prescribed.
Prior to my egg retrieval cycle, I was put onDesiginBCpillsfor21days was off themfor3days prior to starting fertility stimulation injections. I started them onday2ofmyperiod. I had crampsmediumtoseverefromperiod,butnotthedrugs.Ihadalotoftrepidationaboutthefertilitydruginjections.Iwasnotscaredofputtinganeedleinmybody,itwasthemixingofthedrugsanddosageamountsthatpetrifiedme.Itreallywasnotthatbadatall.IwatchedthevideobyaprofessionalnursecoordinatorfromNYUandfeltconfidentthatIwasreadyto mixmydosagesofGonal-F(225iu)andMenopur(150iu)onmyown.Ihadaq-cupandusedthe27 1/2gaugeneedletoassistmeintheprocess. Do not use the 22 ones. Iflickedoutthebubbleswitheaseandevenrememberedtonotshakethecontainerswhenmixing.Imerelyrotatedthemaround.Allinall,itwasasuccessful1stdaywithmyeggfreezingprocess. I had no immediatesideeffects that night.
Cetrotide on lt; Syringe in middle with Menopur and
sodium chloride; Gonal F Pen on rt.
The next day I immediately developed a dull headache that lingered the whole day. I felt really confident when I did my shots on night two. No major hiccups to note. During the first week of stimulation injections, I had a hard time going to sleep, but I did not feel overly emotional or any pain from the drugs. I think I have a higher tolerance of pain than most. By the 7th day, I started to develop a little bruising from the drugs. I am sure that if I went to the beach, people would think I was doing heroine subcutaneously from my abdomen area. It was not a pretty look. Luckily, I was not dating anyone serious at the time. I did go on some dates which I will blog about that separately.
Cetrotide is a drug that prevents the LH surge from happening. This is necessary to prevent ovulation from coming too pre-maturely. Everything has to be timed perfectly to make the magic happen.
So, the Cetrotide stings slightly directly after the injection and for me, created a red circle around the injected area. I used small ice packs to soothe the pain and minimize the itchiness and redness. I am hoping that my body will get used to the shots and that I will no longer get the red areas every time.
Stay tuned for more on Egg Freezing .... True Confessions Eggfreezing101@gmail.com if you have any questions or comments.
I vividly remember the first time someone introduced the subject of egg freezing to me. I was 34 and my OB / GYN glanced at my chart and then me, and asked, "So, have you ever contemplated freezing your eggs or creating an embryo?" To be perfectly honest, I was in shock and a little bit offended. I guess the single, unmarried box, next to my birthdate was her trigger to broach the topic. I was fit, dating someone new, and about to be 35. Why would I need to worry about my biological clock, right?
I mean, everyday I was reading in US Weekly about a different celebrity that gave birth to another child over 40. Couldn't I wait too? What I did not know then was that most of these women were using either egg donors to get pregnant or were doing rounds of IVF (hormone injections and then an embryo transfer) to achieve the same result. I was so naive. The first thing I did on my journey to decide if freezing my eggs was the right thing for me was to educate myself on the process, the potential costs, and to find out what my chances were to have a baby one day with these eggs. I am going to give you my own personal take on the process and the pros and cons to Egg Freezing.
Vogue.com Egg Freezing
Here is a little Egg Freezing 101 and Infertility vocabulary:
AMH: Anti-Mullerian Hormone, also referred to as MIS (Mullerian Inhibiting Substance), is produced by the ovarian follicles. AMH levels correlate with the number of antral follicles in the ovaries and gives an estimate of remaining egg supply. Women with lower AMH have lower antral follicular counts and produce a lower number of eggs compared with women with higher levels. AMH is only one factor that comprises a women's ovarian reserves prognosis. (Women with very low AMH <.2 and > 10 FSH are not good candidates for the egg freezing process.)
Antral follicle count (AFC):The number of follicles detected by the ultrasound at the beginning of the menstrual cycle, which indicates the size of your ovarian reserve.
Chromosomal abnormalities: An atypical number of chromosomes. When numerical abnormalities occur in germ cells (i.e. sperm and egg cells) or during the very early stages of fetal development they may result in a miscarriage or in a developmental abnormality such as Down’s syndrome.
Egg donation: The process by which a woman donates several (usually 10-15) eggs for purposes of ART.
Egg freezing: also called human oocyte cryopreservation, is a rapidly advancing technology of extracting, freezing and storing a woman’s eggs (oocytes). The eggs can later be thawed, fertilized, and transferred to the uterus as embryos months or years later.Reproductive cryopreservation is not new. Medical clinics have been freezing sperm since the 1950s and embryos since the 1980s. Doctors in Australia reported the world’s first pregnancy using frozen oocytes in 1984. Read more at http://rscbayarea.com/learn/egg-freezing#zdMicOEdatyIYIZv.99
Egg vitrification: Instead of slowly being cooled, eggs are quickly vitrified by replacing their water content with a cryoprotectant solution. When ready to be used, vitrified eggs are thawed instead of warmed resulting in decreased rates of ice crystal development that often occurs in the slow cooling method.
Embryo: A fertilized egg that has begun cell division.
Estradiol: The primary female sex hormone. It is formed from developing ovarian follicles and is responsible for female characteristics and sexual functioning. Estradiol levels are also measured in the FSH Day 3 blood exam to check ovarian reserves. For each mature egg, your Estradiol goes up another 200 pg. By your egg retrieval day, you could be over 5000 pg. For more information on estradiol, click here.
Fallopian tubes: Two tubes that transport the egg from the ovary to the uterus (womb).
“Fast” egg freezing: Preferred method for preserving eggs for storage. see egg vitrification
Fertilization: The union of mature male and female gametes (reproductive cells) to form a zygote (or fertilized egg).
FSH: Follicle stimulating hormone; causes follicles to grow
FSH Day 3 Test: Follicle stimulating hormone test is a routine blood test administered on Day 3 of menstruation to measure ovarian reserves. High levels of FSH may indicate poor ovarian reserves while low levels of FSH indicate strong ovarian reserves.
LH: Luteinizing hormone; causes eggs to mature. In the egg freezing process, you want to make sure you control the surge. Drugs like cetrotide and ganelrix delay or suppress the LH surge to give more eggs time to mature before ovulation.
ICSI: Intracytoplasmic sperm injection is used to fertilize frozen eggs. The technique involves directly injecting a single sperm into a single egg with a needle instead of allowing sperm to penetrate the egg naturally in a Petri dish.
In Vitro Fertilization (IVF): The process of fertilization by manually combining an egg and sperm in a laboratory dish. If successful, the fertilized egg or embryo will be transferred to the uterus. For more information, click here.
Mature Egg: An egg housed in a follicle that is between 18mm - 22mm in size. Only mature eggs can be fertilized with sperm to create a healthy embryo.
Menopause: The cessation of ovulation and menstrual cycles.
Oocyte: An immature, or unfertilized, female egg cell.
Oocyte cryopreservation: Commonly referred to as egg freezing, oocyte cryopreservation is a procedure that extracts, freezes and stores unfertilized eggs for future use.
Ovarian Follicles: A cellular structure found in the ovary where immature eggs mature, leading to ovulation and either pregnancy or menstruation.
Ovarian hyperstimulation: The use of fertility drugs to stimulate the ovaries to develop follicles. Not to be confused with OHSS
Ovarian reserves: Indicates a woman’s fertility potential and is commonly used as a barometer for the likelihood of fertility success. Measurements such as FSH, AMH, other hormones, and the renting antral follicle count are used to determine the prognosis of one's OR.
Ovary: One of a pair of reproductive glands located on each side of the uterus. The ovaries produce eggs and female hormones. During a healthy menstrual cycle, one egg is released from one ovary.
Ovulation: Time at which a mature egg is released from the ovary, passed through the fallopian tube and ready for fertilization. It occurs post the LH surge.
“Slow” egg freezing: Process by which female eggs are slowly dehydrated by replacing their water content with small amounts of cryoprotectant, or freezing agent. When the eggs reach minus 32 Celsius they are placed in liquid nitrogen and transformed into a solid.
Ultrasound: A medical imaging technique that uses high frequency sound waves. Ultrasounds are used in egg freezing for visualizing the follicles in the ovaries.
Vitrify: To change or make into glass or a glassy substance.
Vitrification: Instead of slowly being cooled, eggs are quickly vitrified by replacing their water content with a cryoprotectant solution. When ready to be used, vitrified eggs are thawed instead of warmed resulting in decreased rates of ice crystal
Stay tuned for my next blog on how I made the final decision to invest in freezing my own eggs to preserve my fertility for the future.
Reproductive cryopreservation is not new. Medical clinics have been freezing sperm since the 1950s and embryos since the 1980s. Doctors in Australia reported the world’s first pregnancy using frozen oocytes in 1984.
